Gadsby is a 50,000-word novel that doesn’t use the letter E:

“But a man has to think of that, Allan. And you will, as you grow up. My two big sons just put off on that big troop train. I don’t know how long Bill and Julius will stay away. Your big cannon might go Boom! and hit Bill or Julius. Do you know Frank Morgan, Paul Johnson and John Smith? All right; that big cannon might hit that trio, too. Nobody can say who a cannon will hit, Allan. Now, you go right on through Grammar School, and grow up into a big strong man, and don’t think about war;” and Gadsby, standing and gazing far off to Branton Hills’ charming hill district, thought: “I think that will bust up a wild young ambition!”

The author, Ernest Vincent Wright, notes that he could mention no numbers between 6 and 30. And “When introducing young ladies into the story, this is a real barrier; for what young woman wants to have it known that she is over thirty?”