In 1909, 22-year-old housewife Alice Huyler Ramsey drove from New York to San Francisco, covering 3,800 miles in 59 days in a Maxwell touring car. She encountered Indians (hunting jackrabbits) in Nebraska, a posse (hunting a murderer) in Wyoming, bad roads, bad weather, flat tires, and breakdowns. All of this is chronicled in her memorably titled 1961 memoir, Veil, Duster and Tire Iron.
With her went two sisters-in-law and a female friend — none of whom could drive a car.
See also Annie Londonderry.