Alexander Fleming, the discoverer of pencillin, grew “germ paintings” of living bacteria on blotting paper. He made this 4-inch portrait, titled “Guardsman,” in 1933.

“If a paper disc is placed on the surface of an agar plate, the nutrient material diffuses through the paper sufficiently to maintain the growth of many microorganisms implanted on the surface of the paper,” he wrote. “At any stage, growth can be stopped by the introduction of formalin. Finally the paper disc, with the culture on its surface, can be removed, dried, and suitably mounted.”

Here’s a gallery. “Even in Fleming’s time this technique failed to receive much attention or approval. Apparently he prepared a small exhibit of bacterial art for a royal visit to St Mary’s by Queen Mary. The Queen was ‘not amused and hurried past it’ even though it included a patriotic rendition of the Union Jack in bacteria.”