The biologist can push it back to the original protist, and the chemist can push it back to the crystal, but none of them touch the real question of why or how the thing began at all. The astronomer goes back untold million of years and ends in gas and emptiness, and then the mathematician sweeps the whole cosmos into unreality and leaves one with mind as the only thing of which we have any immediate apprehension. Cogito ergo sum, ergo omnia esse videntur. All this bother, and we are no further than Descartes. Have you noticed that the astronomers and mathematicians are much the most cheerful people of the lot? I suppose that perpetually contemplating things on so vast a scale makes them feel either that it doesn’t matter a hoot anyway, or that anything so large and elaborate must have some sense in it somewhere.

— Dorothy L. Sayers, The Documents in the Case, 1930