In 2012 computer scientist Andrew Adamatzky set a plasmodium of the slime mold Physarum polycephalum into a maze with an oat flake at its center. By following a gradient of chemo-attractants given off by the flake, the plasmodium was able to solve the maze in one pass, extending a protoplasmic tube to the target.

The original recording was made at one frame per five minutes; this playback is 25-30 frames per second.

(Andrew Adamatzky, “Slime Mold Solves Maze in One Pass, Assisted by Gradient of Chemo-Attractants,” IEEE Transactions on Nanobioscience 11:2 [2012], 131-134.)