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Franz Liszt’s 1851 étude “La Campanella” is one of the most technically demanding pieces ever written for piano.

In bar 102, below, the left hand has to jump 35 half-steps, nearly three octaves, in the space of a sixteenth note.

That’s about 46 centimeters.

https://commons.wikimedia.org/wiki/File:La_Campanella2.png